Journal: Archives of Toxicology

Article Title: In vitro models to detect in vivo bile acid changes induced by antibiotics

doi: 10.1007/s00204-022-03373-4

Figure Lengend Snippet: Intrinsic fecal bile acid composition and changes (A–I) over time (0 h, 4 h, 8 h, 24 h) in in vitro anaerobic rat fecal incubations with or without (control) treatment with the antibiotics colistin sulfate and tobramycin (* P < 0.05, ** P < 0.01, *** P < 0.001 indicate a difference from the control without antibiotic at the corresponding time point). Results are shown as mean ± SD from three independent incubations

Article Snippet: The fecal samples from tobramycin rats were provided by BASF and taken from an in vivo study in which Wistar rats were orally administrated a series of antibiotics, including tobramycin, for 28 days.

Techniques: In Vitro, Control

Journal: Archives of Toxicology

Article Title: In vitro models to detect in vivo bile acid changes induced by antibiotics

doi: 10.1007/s00204-022-03373-4

Figure Lengend Snippet: Time-dependent deconjugation of taurine conjugated bile acids to their deconjugated metabolites in in vitro anaerobic rat fecal incubations (A–D) in the absence (control) and presence of the antibiotics colistin sulfate and tobramycin (* P < 0.05, ** P < 0.01, *** P < 0.001 indicate a difference from the control without antibiotic at the corresponding time point). Results are shown as mean ± SD from three independent incubations

Article Snippet: The fecal samples from tobramycin rats were provided by BASF and taken from an in vivo study in which Wistar rats were orally administrated a series of antibiotics, including tobramycin, for 28 days.

Techniques: In Vitro, Control

Journal: Archives of Toxicology

Article Title: In vitro models to detect in vivo bile acid changes induced by antibiotics

doi: 10.1007/s00204-022-03373-4

Figure Lengend Snippet: Time-dependent deconjugation of glycine conjugated bile acids to their deconjugated metabolites in in vitro anaerobic rat fecal incubations (A–D) in the absence (control) and presence of the antibiotics colistin sulfate and tobramycin (* P < 0.05, ** P < 0.01, *** P < 0.001 indicate a difference from the control without antibiotic at the corresponding time point). Results are shown as mean ± SD from three independent incubations

Article Snippet: The fecal samples from tobramycin rats were provided by BASF and taken from an in vivo study in which Wistar rats were orally administrated a series of antibiotics, including tobramycin, for 28 days.

Techniques: In Vitro, Control

Journal: Archives of Toxicology

Article Title: In vitro models to detect in vivo bile acid changes induced by antibiotics

doi: 10.1007/s00204-022-03373-4

Figure Lengend Snippet: Time-dependent deconjugation of TCA ( A ) and formation of its metabolite CA ( B ) in in vitro anaerobic incubations with fecal samples from rats exposed for 23 days to 0 (control) or 1000 mg/kg bw/day tobramycin in vivo (* P < 0.05, ** P < 0.01, **** P < 0.0001 indicate a difference from the control without antibiotic at the corresponding time point). Results are shown as mean ± SD from three independent incubations

Article Snippet: The fecal samples from tobramycin rats were provided by BASF and taken from an in vivo study in which Wistar rats were orally administrated a series of antibiotics, including tobramycin, for 28 days.

Techniques: In Vitro, Control, In Vivo

Journal: Archives of Toxicology

Article Title: In vitro models to detect in vivo bile acid changes induced by antibiotics

doi: 10.1007/s00204-022-03373-4

Figure Lengend Snippet: Time-dependent translocation of TCA across a Caco-2 cell layer upon pre-exposure with 45 mM tobramycin or without tobramycin (control) (* P < 0.05 indicates a difference from the control without antibiotic at the corresponding time point). Results are shown as mean ± SD from four independent experiments

Article Snippet: The fecal samples from tobramycin rats were provided by BASF and taken from an in vivo study in which Wistar rats were orally administrated a series of antibiotics, including tobramycin, for 28 days.

Techniques: Translocation Assay, Control